Targeted treatment with pazopanib in metastatic soft tissue sarcoma: Nearly complete response in two cases.

Abstract

Soft tissue sarcomas (STS) are a group of rare mesenchymal cancers that include approximately 50 histological types and account for 1% of all adult cancers. The standard curative treatment option for localized disease is surgical resection and, if a surgically removed tumor exhibits high-risk characteristics, adjuvant chemotherapy and radiotherapy may be administered. Sarcoma presenting at an advanced stage has a dismal prognosis and survival has not markedly improved over the last 20 years. The standard first-line treatment for advanced STS, other than gastrointestinal stromal tumors, is cytotoxic chemotherapy. Therapies targeting pro-angiogenic factors have been a focus of drug development for STS over the last few years. Pazopanib, a multitargeted tyrosine kinase inhibitor, is a novel treatment option for patients with metastatic STS in the second-line setting. This is a presentation of 2 case reports of patients with metastatic STS who responded well to treatment with pazopanib.

• Authors: Ali Murat Sedef, Fatih Köse, Özlem Doğan, Tarkan Ergün, Ahmet Sezer, Hüseyin Mertsoylu, Sadik Muallaoğlu, Ayberk Beşen, Özgur Özyilkan
• Journal: Molecular and clinical oncology (Mol Clin Oncol) Vol. 3 Issue 2 Pg. 400-402 (Mar 2015) ISSN: 2049-9450 [Print] England
• PMID: 25798275 (Publication Type: Journal Article)