Effects of 2-amino-7-phosphonoheptanoic acid on EEG of rats.

Abstract

2-APH is an antagonist of excitation due to dicarboxylic amino acids and has a protective effect against several types of experimental seizures. We have studied its effect on EEG of rats. Following either intracerebroventricular or intraperitoneal administration of 2-APH produces slow waves of high voltage in central cortex. The anticonvulsant action of this drug may be related to altered activity in neurones of this area.

• Authors: J C Rostain, B Wardley-Smith, B S Meldrum
• Journal: Electroencephalography and clinical neurophysiology (Electroencephalogr Clin Neurophysiol) Vol. 60 Issue 4 Pg. 367-9 (Apr 1985) ISSN: 0013-4694 [Print] Ireland
• PMID: 2579803 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Amino Acids
• 2-Amino-5-phosphonovalerate
• 2-amino-7-phosphonoheptanoic acid

Topics

• 2-Amino-5-phosphonovalerate (analogs & derivatives)
• Amino Acids (pharmacology)
• Animals
• Brain (drug effects, physiology)
• Electroencephalography
• Electrophysiology
• Male
• Rats
• Rats, Inbred Strains