Abstract | OBJECTIVE: Carica papaya is an important fruit with its seeds used in the treatment of ulcer in Nigeria. This study investigated the anti-ulcerogenic and antioxidant activities of aqueous extract of Carica papaya seed against indomethacin-induced peptic ulcer in male rats. METHODS: Thirty male rats were separated into 6 groups (A-F) of five rats each. For 14 d before ulcer induction with indomethacin, groups received once daily oral doses of vehicle (distilled water), cimetidine 200 mg/kg body weight (BW), or aqueous extract of C. papaya seed at doses of 100, 150 or 200 mg/kg BW (groups A, B, C, D, E and F, respectively). Twenty-four hours after the last treatment, groups B, C, D, E and F were treated with 100 mg/kg BW of indomethacin to induce ulcer formation. RESULTS: CONCLUSION:
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Authors | Hussein O B Oloyede, Matthew C Adaja, Taofeek O Ajiboye, Musa O Salawu |
Journal | Journal of integrative medicine
(J Integr Med)
Vol. 13
Issue 2
Pg. 105-14
(Mar 2015)
ISSN: 2095-4964 [Print] Netherlands |
PMID | 25797641
(Publication Type: Journal Article)
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Chemical References |
- Anti-Ulcer Agents
- Plant Extracts
- Indomethacin
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Topics |
- Animals
- Anti-Ulcer Agents
(administration & dosage)
- Carica
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Duodenal Ulcer
(chemically induced, diagnosis, drug therapy)
- Gastric Acidity Determination
- Indomethacin
(pharmacology)
- Male
- Peptic Ulcer
(chemically induced, diagnosis, drug therapy)
- Plant Extracts
(administration & dosage)
- Rats
- Seeds
- Stomach Ulcer
(chemically induced, diagnosis, drug therapy)
- Treatment Outcome
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