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Personalizing the diuretic treatment of hypertension: the need for more clinical and research attention.

Abstract
Neither randomized controlled trials nor efforts to identify genetic markers have been helpful with regard to the goal of individualizing diuretic therapy in the treatment of hypertension, a goal that receives little clinical or research attention. This review will examine, and bring attention to, the considerable yet overlooked information relevant to individualizing diuretic therapy. It will bring attention to clinical, biochemical, and pharmacological clues that can be helpful in identifying who is likely to respond to a diuretic, who needs a stronger diuretic regimen, which diuretic to prescribe, and how to minimize adverse effects. New directions for clinical research aimed at individualizing use in hypertension will be explored. Research and clinical attention to the goal of individualizing diuretic treatment in hypertension need to be renewed, to help us achieve greater hypertension control with fewer adverse effects and lower costs.
AuthorsSamuel J Mann, Michael E Ernst
JournalCurrent hypertension reports (Curr Hypertens Rep) Vol. 17 Issue 4 Pg. 542 (Apr 2015) ISSN: 1534-3111 [Electronic] United States
PMID25794956 (Publication Type: Journal Article, Review)
Chemical References
  • Diuretics
  • Epithelial Sodium Channels
  • Mineralocorticoid Receptor Antagonists
  • Potassium
Topics
  • Diuretics (therapeutic use)
  • Epithelial Sodium Channels (metabolism)
  • Humans
  • Hypertension (drug therapy)
  • Mineralocorticoid Receptor Antagonists (therapeutic use)
  • Potassium (metabolism)
  • Precision Medicine

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