Abstract | BACKGROUND: METHODS: During a 32-patient study randomized between hypothermia only and hypothermia with xenon, 5 neonates were given xenon during retrieval using a closed-circuit incubator-mounted system. RESULTS: Without xenon availability during retrieval, 50% of eligible infants exceeded the 5-hour treatment window. With the transportable system, 100% were recruited. Xenon delivery lasted 55 to 120 minutes, using 174 mL/h (117.5-193.2) (median [interquartile range]), after circuit priming (1300 mL). CONCLUSIONS:
Xenon delivery during ambulance retrieval was feasible, reduced starting delays, and used very little gas.
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Authors | John Dingley, Xun Liu, Hannah Gill, Elisa Smit, Hemmen Sabir, James Tooley, Ela Chakkarapani, David Windsor, Marianne Thoresen |
Journal | Anesthesia and analgesia
(Anesth Analg)
Vol. 120
Issue 6
Pg. 1331-6
(Jun 2015)
ISSN: 1526-7598 [Electronic] United States |
PMID | 25794112
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Administration, Inhalation
- Ambulances
- Anesthesia, Closed-Circuit
(instrumentation)
- Asphyxia Neonatorum
(therapy)
- Emergency Medical Services
- England
- Equipment Design
- Feasibility Studies
- Humans
- Hypothermia, Induced
- Infant, Newborn
- Point-of-Care Systems
- Prospective Studies
- Respiration, Artificial
(instrumentation)
- Time Factors
- Treatment Outcome
- Ventilators, Mechanical
- Xenon
(administration & dosage)
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