Abstract | OBJECTIVE: APPROACH AND RESULTS: Thirty-nine rabbits on a 13-week regimen of 0.5% cholesterol diet were included. Periodontitis was induced by Porphyromonas gingivalis in 24 rabbits and 15 rabbits were placed in no- periodontitis groups. Interventions were no-treatment, vehicle, and RvE1 treatment (4 μg/site or 0.4 μg/site) topically applied 3× per week. At 13 weeks, both periodontitis and atherosclerosis were quantified. Atherosclerotic plaques were assessed by Sudan IV staining, histology, and ex vivo MRI. Serum levels of C-reactive protein were evaluated as a measure of systemic inflammation. RvE1, used as an oral/topical agent, significantly diminished atherogenesis and prevented periodontitis (P<0.05). In the absence of periodontal inflammation, oral/topical application of RvE1 resulted in significantly less arterial plaque, a lower intima/media ratio, and decreased inflammatory cell infiltration compared with no-treatment (P<0.001). Local oral RvE1 application significantly reduced systemic levels of C-reactive protein (P<0.05). CONCLUSIONS:
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Authors | Hatice Hasturk, Rima Abdallah, Alpdogan Kantarci, Daniel Nguyen, Nicholas Giordano, James Hamilton, Thomas E Van Dyke |
Journal | Arteriosclerosis, thrombosis, and vascular biology
(Arterioscler Thromb Vasc Biol)
Vol. 35
Issue 5
Pg. 1123-33
(May 2015)
ISSN: 1524-4636 [Electronic] United States |
PMID | 25792445
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | © 2015 American Heart Association, Inc. |
Chemical References |
- C-Reactive Protein
- Eicosapentaenoic Acid
- 5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid
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Topics |
- Administration, Topical
- Animals
- Atherosclerosis
(pathology, prevention & control)
- Biopsy, Needle
- C-Reactive Protein
(metabolism)
- Diet, Atherogenic
- Disease Models, Animal
- Eicosapentaenoic Acid
(analogs & derivatives, pharmacology)
- Immunohistochemistry
- Inflammation
(complications, physiopathology)
- Male
- Periodontitis
(complications, drug therapy, pathology)
- Rabbits
- Random Allocation
- Reference Values
- Risk Assessment
- Treatment Outcome
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