HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

The effect of mycophenolic acid on epigenetic modifications in lupus CD4+T cells.

Abstract
Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease involving multiple organs and characterized by overproduction of autoantibodies and T and B cell abnormalities. The treatment for SLE has been restricted to immunosuppressants and corticosteroids. Mycophenolate mofetil (MMF), as a relatively new immunosuppressant, is now widely used in the treatment of SLE patients, particularly those with nephritis. However, it is unclear whether mycophenolic acid (MPA) could modulate the reported disorders of epigenetic status in CD4(+)T cells from SLE patients. In this study, we demonstrated that MPA can upregulate the histone H3/H4 global acetylation status by regulating HATs and HDACs in lupus CD4(+)T cells. Furthermore, we found that MPA also affected the histone H4 acetylation and histone H3K4 tri-methylation levels in CD40L promoter region that inhibited the expression of CD40L. These findings indicate the potential epigenetic mechanism of therapeutic effects of MPA in SLE.
AuthorsYang Yang, Qian Tang, Ming Zhao, Gongping Liang, Haijing Wu, Duo Li, Yubing Xie, Yixin Tan, Yong Dai, Susan Yung, Tak Mao Chan, Qianjin Lu
JournalClinical immunology (Orlando, Fla.) (Clin Immunol) Vol. 158 Issue 1 Pg. 67-76 (May 2015) ISSN: 1521-7035 [Electronic] United States
PMID25791245 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2015 Elsevier Inc. All rights reserved.
Chemical References
  • CD11a Antigen
  • CD27 Ligand
  • Enzyme Inhibitors
  • Histones
  • RNA, Messenger
  • CD40 Ligand
  • Histone Deacetylases
  • Mycophenolic Acid
Topics
  • Acetylation (drug effects)
  • Adult
  • CD11a Antigen (drug effects, metabolism)
  • CD27 Ligand (drug effects, metabolism)
  • CD4-Positive T-Lymphocytes (drug effects, immunology)
  • CD40 Ligand (drug effects, metabolism)
  • Case-Control Studies
  • Cells, Cultured
  • DNA Methylation (drug effects)
  • Enzyme Inhibitors (pharmacology)
  • Epigenesis, Genetic (drug effects, immunology)
  • Female
  • Histone Deacetylases (drug effects, genetics, metabolism)
  • Histones (drug effects, metabolism)
  • Humans
  • Lupus Erythematosus, Systemic (immunology)
  • Methylation (drug effects)
  • Middle Aged
  • Mycophenolic Acid (pharmacology)
  • RNA, Messenger (drug effects, metabolism)
  • Young Adult

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: