Abstract | OBJECTIVE: METHODS: From January 2011 to January 2013 recruited were 90 RA inpatients of ADHS at Department of Integrative Medicine on Rheumatoid Disease, General Hospital of Chengdu Military Region. They were assigned to the treatment group (45 cases) and the control group (45 cases) according to the random digit table produced by SPSS 11.5 Software. Patients in the treatment group were treated by heavy bitter-cold herbs plus SYD combined with MTX, while those in the control group were treated by MTX alone. Expressional levels of IL-1, IL-6, and IL-17 in serum were detected by enzyme linked immunosorbent assay (ELISA) before treatment, at week 2 and 4 after treatment. Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and disease activity score in 28 joints (DAS28) were detected as well. RESULTS: After two or four weeks of treatment, ESR, CRP, and DAS28 decreased more in the treatment group than in the control group with statistical difference (P < 0.05, P < 0.01). After four weeks of treatment, IL-1, IL-6, IL-17, ESR, CRP, and DAS28 in the treatment group were all lower than before treatment and those of the control group at corresponding time points with statistical difference (P < 0.01). CONCLUSION: SYD combined MTX could play roles of improving inflammatory indices within 2 weeks, and inhibiting the expression of IL-1, IL-6, and IL-17 within 4 weeks.
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Authors | Liu De-Fang, Yong Luo, Jiao Yan, Wei Zou, Guo Min, Yong-He Hu, Min Yang, Jun Zhang, Ming-Dong Yun, Kun Li, Yang Mei, Hua Li |
Journal | Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
(Zhongguo Zhong Xi Yi Jie He Za Zhi)
Vol. 35
Issue 1
Pg. 33-6
(Jan 2015)
ISSN: 1003-5370 [Print] China |
PMID | 25790671
(Publication Type: Journal Article)
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Chemical References |
- Drugs, Chinese Herbal
- Interleukin-1
- Interleukin-17
- Interleukin-6
- sanhuang
- C-Reactive Protein
- Methotrexate
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Topics |
- Arthritis, Rheumatoid
(blood, drug therapy, immunology)
- Blood Sedimentation
- C-Reactive Protein
- Drug Therapy, Combination
- Drugs, Chinese Herbal
(therapeutic use)
- Hot Temperature
- Humans
- Interleukin-1
(blood)
- Interleukin-17
(blood)
- Interleukin-6
(blood)
- Methotrexate
(therapeutic use)
- Syndrome
- Treatment Outcome
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