Successful treatment with sirolimus for an angiomyolipoma mimicking renal cell carcinoma in a transplanted kidney.

Abstract

Angiomyolipoma (AML) is a benign mesenchymal tumor composed of blood vessels, smooth muscle, and mature adipose tissue. AMLs in the kidney allografts are rare. We report a case of AML that was incidentally found 1 year after transplantation. Abdominal computed tomography showed a 4-cm renal tumor with contrast enhancement and an early washout pattern, resembling a renal cell carcinoma. Tumor biopsy proved a lipid-poor AML. Tumor diameter decreased to 2.4 cm after 6 months of treatment with sirolimus. Sirolimus not only reduces tumor size, but also benefits a transplant patient who needs immunosuppression.

• Authors: Hsien-Fu Chiu, Mei-Chin Wen, Jian-Ri Li, Hao-Chung Ho, Kuo-Hsiung Shu
• Journal: Transplant international : official journal of the European Society for Organ Transplantation (Transpl Int) Vol. 28 Issue 9 Pg. 1116-20 (Sep 2015) ISSN: 1432-2277 [Electronic] Switzerland
• PMID: 25790294 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2015 Steunstichting ESOT.

Chemical References

• Immunosuppressive Agents
• MTOR protein, human
• TOR Serine-Threonine Kinases
• Sirolimus

Topics

• Adult
• Angiomyolipoma (complications, drug therapy)
• Biopsy
• Carcinoma, Renal Cell (diagnosis)
• Diagnosis, Differential
• Female
• Humans
• Immunosuppression Therapy
• Immunosuppressive Agents (therapeutic use)
• Kidney (pathology)
• Kidney Neoplasms (complications, drug therapy)
• Kidney Transplantation (adverse effects)
• Nephrectomy
• Renal Insufficiency (complications, surgery)
• Sirolimus (therapeutic use)
• TOR Serine-Threonine Kinases (metabolism)
• Tomography, X-Ray Computed
• Treatment Outcome