Prognostic significance of anti-aminoacyl-tRNA synthetase antibodies in polymyositis/dermatomyositis-associated interstitial lung disease: a retrospective case control study.

Abstract

BACKGROUND:

In polymyositis/dermatomyositis (PM/DM), anti-aminoacyl-tRNA synthetase (ARS) antibodies are closely associated with interstitial lung disease (ILD), a frequent pulmonary complication. However, the clinical significance of anti-ARS antibodies is not well established.

OBJECTIVE:

We aimed to evaluate the clinical significance of anti-ARS antibodies in PM/DM-ILD patients.

METHODS:

Forty-eight consecutive PM/DM-ILD patients were studied retrospectively. Anti-ARS antibodies were screened by ELISA and confirmed by RNA immunoprecipitation test. Medical records, high-resolution computed tomography images, and surgical lung biopsy specimens were compared between ARS-positive (ARS group) and ARS-negative patients (non-ARS group).

RESULTS:

Anti-ARS antibodies were detected in 23 of 48 patients (48%). Radiologically, nonspecific interstitial pneumonia (NSIP) pattern was observed more frequently in the ARS group than in the non-ARS group (73.9% vs. 40%, P = 0.02). Pathologically, NSIP was the most frequent in both groups. Ten-year survival rate was also significantly higher in the ARS group than in the non-ARS group (91.6% vs. 58.7%, P = 0.02). Univariate Cox hazards analysis revealed that the presence of anti-ARS antibodies was associated with better prognosis (HR = 0.34, 95% CI 0.08-0.80; P = 0.01).

CONCLUSIONS:

The presence of anti-ARS antibodies is a possible prognostic marker in patients with PM/DM-ILD.

• Authors: Hironao Hozumi, Noriyuki Enomoto, Masato Kono, Tomoyuki Fujisawa, Naoki Inui, Yutaro Nakamura, Hiromitsu Sumikawa, Takeshi Johkoh, Ran Nakashima, Yoshitaka Imura, Tsuneyo Mimori, Takafumi Suda
• Journal: PloS one (PLoS One) Vol. 10 Issue 3 Pg. e0120313 ( 2015) ISSN: 1932-6203 [Electronic] United States
• PMID: 25789468 (Publication Type: Journal Article)

Chemical References

• Autoantibodies
• Biomarkers
• Amino Acyl-tRNA Synthetases

Topics

• Adult
• Aged
• Amino Acyl-tRNA Synthetases (immunology)
• Autoantibodies (analysis, immunology)
• Biomarkers (analysis)
• Case-Control Studies
• Dermatomyositis (complications, mortality, pathology)
• Enzyme-Linked Immunosorbent Assay
• Female
• Humans
• Immunoprecipitation
• Kaplan-Meier Estimate
• Lung Diseases, Interstitial (complications, diagnosis, mortality)
• Male
• Middle Aged
• Polymyositis (complications, mortality, pathology)
• Prognosis
• Proportional Hazards Models
• Retrospective Studies
• Tomography, X-Ray Computed