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Brain-derived neurotrophic factor inhibits calcium channel activation, exocytosis, and endocytosis at a central nerve terminal.

Abstract
Brain-derived neurotrophic factor (BDNF) is a neurotrophin that regulates synaptic function and plasticity and plays important roles in neuronal development, survival, and brain disorders. Despite such diverse and important roles, how BDNF, or more generally speaking, neurotrophins affect synapses, particularly nerve terminals, remains unclear. By measuring calcium currents and membrane capacitance during depolarization at a large mammalian central nerve terminal, the rat calyx of Held, we report for the first time that BDNF slows down calcium channel activation, including P/Q-type channels, and inhibits exocytosis induced by brief depolarization or single action potentials, inhibits slow and rapid endocytosis, and inhibits vesicle mobilization to the readily releasable pool. These presynaptic mechanisms may contribute to the important roles of BDNF in regulating synapses and neuronal circuits and suggest that regulation of presynaptic calcium channels, exocytosis, and endocytosis are potential mechanisms by which neurotrophins achieve diverse neuronal functions.
AuthorsMaryna Baydyuk, Xin-Sheng Wu, Liming He, Ling-Gang Wu
JournalThe Journal of neuroscience : the official journal of the Society for Neuroscience (J Neurosci) Vol. 35 Issue 11 Pg. 4676-82 (Mar 18 2015) ISSN: 1529-2401 [Electronic] United States
PMID25788684 (Publication Type: Journal Article, Research Support, N.I.H., Intramural)
CopyrightCopyright © 2015 the authors 0270-6474/15/354676-07$15.00/0.
Chemical References
  • Brain-Derived Neurotrophic Factor
  • Calcium Channel Agonists
Topics
  • Animals
  • Brain-Derived Neurotrophic Factor (pharmacology)
  • Calcium Channel Agonists (pharmacology)
  • Endocytosis (drug effects, physiology)
  • Excitatory Postsynaptic Potentials (drug effects, physiology)
  • Exocytosis (drug effects, physiology)
  • Female
  • Male
  • Mice, Transgenic
  • Organ Culture Techniques
  • Presynaptic Terminals (drug effects, physiology)
  • Rats
  • Rats, Wistar

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