Abstract | INTRODUCTION: The centrosome plays an essential role in the cell cycle. The centrosome and its associated proteins assist in nucleating and organizing microtubules. A structural or a functional aberration in the centrosome is known to cause abnormal cell proliferation leading to tumors. Therefore, the centrosome is considered as a promising anti- cancer target. AREAS COVERED: EXPERT OPINION: Insights into the functioning of the centrosomal proteins will be extremely beneficial in validating the centrosome as a target in cancer therapy. New strategies either as a single entity or in combination with current chemotherapeutic agents should be researched or exploited to reveal the promises that the centrosome holds for future cancer therapy.
|
Authors | Jubina B Venghateri, Bhavya Jindal, Dulal Panda |
Journal | Expert opinion on therapeutic targets
(Expert Opin Ther Targets)
Vol. 19
Issue 7
Pg. 957-72
(Jul 2015)
ISSN: 1744-7631 [Electronic] England |
PMID | 25787715
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
|
Chemical References |
|
Topics |
- Animals
- Antineoplastic Agents
(administration & dosage, pharmacology)
- Cell Cycle
(physiology)
- Cell Proliferation
(physiology)
- Centrosome
(metabolism)
- Humans
- Molecular Targeted Therapy
- Neoplasms
(drug therapy, pathology)
|