Intravenous fasudil improves in-hospital mortality of patients with right heart failure in severe pulmonary hypertension.

Abstract

The in-hospital mortality of severe pulmonary hypertension (PH) with right heart failure (RHF) is high despite the use of vasoactive and PH-specific therapies. We conducted a prospective analysis evaluating the safety and outcomes of fasudil hydrochloride (Chuan Wei) therapy in acute RHF. PH patients hospitalized between April 2009 and November 2010 were treated with 30 mg of i.v. fasudil three times daily over 30 min, until they experienced relief of RHF symptoms. Adverse and serious adverse events were recorded. Odds ratios (ORs) and 95% confidence intervals were calculated for both in-hospital mortality and re-hospitalization. Multivariate adjustments were made for age, gender and World Health Organization functional class. There were no significant differences between the fasudil group and the control group in demographics, hemodynamics, and PH-specific and vasoactive therapies. Of the 209 study patients, 3 of the 74 patients (4.1%) in the fasudil arm died, and 19 of the 135 patients (14.1%) in the control arm died (P=0.005). Fasudil decreased both in-hospital mortality (OR=0.258 (0.074-0.903); P=0.034) and 30-day re-hospitalization (OR=0.200 (0.059-0.681); P=0.010). Fasudil was well tolerated; one patient discontinued treatment. Intravenous fasudil may be given safely in patients with PH and acute RHF, and may reduce the rates of both in-hospital mortality and 30-day re-hospitalization.

• Authors: Rong Jiang, Zi-Sheng Ai, Xin Jiang, Ping Yuan, Dong Liu, Qin-Hua Zhao, Jing He, Lan Wang, Mardi Gomberg-Maitland, Zhi-Cheng Jing
• Journal: Hypertension research : official journal of the Japanese Society of Hypertension (Hypertens Res) Vol. 38 Issue 8 Pg. 539-44 (Aug 2015) ISSN: 1348-4214 [Electronic] England
• PMID: 25787034 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Vasodilator Agents
• 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
• fasudil

Topics

• 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine (administration & dosage, analogs & derivatives, therapeutic use)
• Administration, Intravenous
• Adult
• Female
• Heart Failure (complications, drug therapy, mortality)
• Hospital Mortality
• Humans
• Hypertension, Pulmonary (complications, drug therapy, mortality)
• Male
• Middle Aged
• Prospective Studies
• Treatment Outcome
• Vasodilator Agents (administration & dosage, therapeutic use)
• Ventricular Dysfunction, Right (complications, drug therapy, mortality)