Abstract | INTRODUCTION: MATERIAL AND METHODS: RESULTS: P1: specific IgE and skin tests were positive for Vespula species; tryptase 52.8 ng/ml; P2: specific IgE and skin tests were positive for Vespa cabro and tryptase 153 ng/ml. Bone marrow biopsy results were negative for mastocytosis. We carried out magnetic resonance imaging, in P1 to better characterize the severe osteoporosis and in P2 because during physical examination a pulsating mass had been identified in the mesogastrium, and an aneurysm of the abdominal aorta which required surgical intervention in both patients was detected. Eight months after surgery, tryptase levels had diminished significantly (P1: 11.6 ng/ml and P2: 14.5 ng/ml). DISCUSSION: The elevated tryptase levels were correlated to abdominal aneurysm in both patients. In fact, post-surgery tryptase levels dramatically decreased. These two cases demonstrate that high tryptase levels in subjects with a history of hymenoptera venom anaphylaxis can be associated to undiagnosed aneurysmatic disease.
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Authors | E A Pastorello, J W Schroeder, S M Veronese, V Pravettoni, A De Gasperi, S Cantoni, L Losappio, L Farioli, R Qualizza, B Scarpati, A Mascheri, J Scibilia |
Journal | European annals of allergy and clinical immunology
(Eur Ann Allergy Clin Immunol)
Vol. 47
Issue 2
Pg. 58-61
(Mar 2015)
ISSN: 1764-1489 [Print] Italy |
PMID | 25781196
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Biomarkers
- Wasp Venoms
- Tryptases
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Topics |
- Aged
- Anaphylaxis
(blood, diagnosis, enzymology, immunology, therapy)
- Animals
- Aortic Aneurysm, Abdominal
(diagnosis, enzymology, surgery)
- Biomarkers
(blood)
- Humans
- Immunotherapy
(methods)
- Insect Bites and Stings
(immunology)
- Male
- Skin Tests
- Time Factors
- Treatment Outcome
- Tryptases
(blood)
- Up-Regulation
- Wasp Venoms
(immunology, therapeutic use)
- Wasps
(immunology)
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