Targeted concurrent chemoradiotherapy, by using improved microcapsules that release carboplatin in response to radiation, improves detectability by computed tomography as well as antitumor activity while reducing adverse effect in vivo.

Abstract

PURPOSE:

The effect of alginate-hyaluronate microcapsules that release carboplatin in response to radiation was improved by adding ascorbic acid (AA).

MATERIALS AND METHODS:

Four measures of the effectiveness of the microcapsules were evaluated: 1) release of carboplatin in response to radiation in vitro and in vivo; 2) detectability of their accumulation by computed tomography (CT) in vivo; 3) enhancement of antitumor effects in vivo; and 4) reduction of adverse effects in vivo.

RESULTS:

There were significant increases in the rupture of microcapsules by adding AA in vitro. Subcutaneously injected microcapsules around the tumor could be detected by using CT and the alteration of CT-values correlated with the accumulation of the microcapsules. Those microcapsules released carboplatin and resulted in synergistic antitumor effect with concomitant radiation. With the encapsulation of carboplatin, chemotherapeutic effects were still observed two weeks after treatment. However, addition of AA did not result in increased antitumor effect in vivo. A reduction in adverse effects was observed with the encapsulation of carboplatin, through localization of carboplatin around the tumor.

CONCLUSION:

Addition of AA to the materials of microcapsules did not result in increasing antitumor effect. However encapsulation of carboplatin will be useful as a clinical cancer-therapy option.

• Authors: Satoshi Harada, Shigeru Ehara, Keizo Ishii, Takahiro Sato, Masashi Koka, Tomihiro Kamiya, Koichiro Sera, Shyoko Goto
• Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (Biomed Pharmacother) Vol. 70 Pg. 196-205 (Mar 2015) ISSN: 1950-6007 [Electronic] France
• PMID: 25776501 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 Elsevier Masson SAS. All rights reserved.

Chemical References

• Antineoplastic Agents
• Capsules
• Delayed-Action Preparations
• Drug Carriers
• Carboplatin

Topics

• Animals
• Antineoplastic Agents (administration & dosage)
• Capsules (administration & dosage, radiation effects)
• Carboplatin (administration & dosage, radiation effects)
• Chemoradiotherapy (methods)
• Delayed-Action Preparations (administration & dosage, radiation effects)
• Drug Carriers (administration & dosage, radiation effects)
• Male
• Mice
• Mice, Inbred BALB C
• Neoplasms (diagnostic imaging, therapy)
• Tomography, X-Ray Computed
• Xenograft Model Antitumor Assays (methods)