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Involvement of the serotonergic system of the ventral hippocampus (CA3) on amnesia induced by ACPA in mice.

Abstract
Interactions between the cannabinoid and serotonin systems have been reported in many studies. In the present study, we investigated the influence of the serotonergic receptor agents on amnesia induced by the cannabinoid CB1 receptor agonist, arachydonilcyclopropylamide (ACPA). Bilateral guide-cannulae were implanted to allow intra-CA3 microinjection of the drugs. The results showed that the intra-peritoneal (i.p.) injection of ACPA induce amnesia but did not alter head dip latency, head dip counts, and locomotion. Moreover, intra-CA3 injection of M-Chlorophenylbiguanide (M-CHL, a 5-HT3 serotonin receptor agonist), Y-25130 (a 5-HT3 serotonin receptor antagonist), RS67333 (a 5-HT4 serotonin receptor agonist), and RS23597-190 (a 5-HT4 serotonin receptor antagonist) impaired memory but have no effect on head dip latency and locomotor activity. In addition, intra-CA3 injection of Y-25130, RS67333, and RS23597-190 heighten the ACPA-induced amnesia and head dip counts while did not alter head dip latency and locomotor activity. On the other hand, intra-CA3 microinjection of M-CHL could not modify the ACPA-induced amnesia, head dip latency and locomotor activity whereas increased head dip counts. It can be concluded that the amnesia induced by i.p. administration of ACPA is at least partly mediated through the serotonergic receptor mechanism in the CA3 area.
AuthorsMohammad Nasehi, Faezeh Kafi, Fatemeh Khakpai, Mohammad-Reza Zarrindast
JournalBehavioural brain research (Behav Brain Res) Vol. 286 Pg. 356-63 (Jun 01 2015) ISSN: 1872-7549 [Electronic] Netherlands
PMID25771207 (Publication Type: Journal Article)
CopyrightCopyright © 2015 Elsevier B.V. All rights reserved.
Chemical References
  • 3-(piperidine-1-yl)propyl 4-amino-5-chloro-2-methoxybenzoate hydrochloride
  • Aniline Compounds
  • Arachidonic Acids
  • Biguanides
  • Bridged Bicyclo Compounds, Heterocyclic
  • Cannabinoid Receptor Agonists
  • Oxazines
  • Piperidines
  • Receptor, Cannabinoid, CB1
  • Receptors, Serotonin, 5-HT3
  • Serotonin Antagonists
  • Serotonin Receptor Agonists
  • arachidonylcyclopropylamide
  • para-Aminobenzoates
  • Receptors, Serotonin, 5-HT4
  • RS 67333
  • Serotonin
  • azasetron
  • 1-(3-chlorophenyl)biguanide
Topics
  • Amnesia (chemically induced, drug therapy, metabolism)
  • Aniline Compounds (pharmacology)
  • Animals
  • Arachidonic Acids (toxicity)
  • Biguanides (pharmacology)
  • Bridged Bicyclo Compounds, Heterocyclic (pharmacology)
  • CA3 Region, Hippocampal (physiopathology)
  • Cannabinoid Receptor Agonists (toxicity)
  • Catheters, Indwelling
  • Male
  • Mice
  • Oxazines (pharmacology)
  • Piperidines (pharmacology)
  • Receptor, Cannabinoid, CB1 (agonists, metabolism)
  • Receptors, Serotonin, 5-HT3 (metabolism)
  • Receptors, Serotonin, 5-HT4 (metabolism)
  • Serotonin (metabolism)
  • Serotonin Antagonists (pharmacology)
  • Serotonin Receptor Agonists (pharmacology)
  • para-Aminobenzoates (pharmacology)

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