Outbreak of trichinellosis due to wild boar meat and evaluation of the effectiveness of post exposure prophylaxis, Germany, 2013.

Abstract

BACKGROUND:

Food safety authorities discovered that wild boar meat products contaminated with Trichinella spiralis had entered the food chain in Germany in March 2013. Public health authorities issued guidelines for health professionals including post-exposure prophylaxis (PEP) using mebendazole and advised the public to seek medical advice if exposed. Our objective was to identify factors associated with the development of trichinellosis and to evaluate post exposure prophylaxis.

METHODS:

Persons who reported to local public health departments as exposed were interviewed concerning exposure, symptoms, and medication. Serum samples were tested by an in-house Trichinella-specific enzyme-linked innunosorbent assay. Cases were defined as persons presenting with myalgia and/or periorbital edema and Trichinella-specific immunoglobulin M and immunoglobulin G antibodies after exposure to implicated products.

RESULTS:

Of 101 persons interviewed, 71 were exposed and serologically tested. Antibodies were detected in 21/71 (30%) and 14/71 (20%) met the case definition. Attack rates were positively correlated to the amount of implicated product consumed. Among n = 37 persons who received anthelmintics as PEP, 6 persons developed trichinellosis. These cases exclusively occurred among persons starting PEP 6 days or later post-exposure. Exposure to implicated products and delaying PEP were also significantly associated with developing trichinellosis (P < .01) in a multivariable analysis.

CONCLUSIONS:

Concerted efforts by food safety and public health authorities lead to timely outbreak control and facilitated the provision of early PEP. PEP appears to be effective in preventing trichinellosis when given early, preferably within 6 days. We therefore recommend initiating PEP without delay in similar settings and encourage public health professionals to fast-track this intervention.

• Authors: Mirko Faber, Susanne Schink, Anne Mayer-Scholl, Christoph Ziesch, Ralph Schönfelder, Heidi Wichmann-Schauer, Klaus Stark, Karsten Nöckler
• Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (Clin Infect Dis) Vol. 60 Issue 12 Pg. e98-e104 (Jun 15 2015) ISSN: 1537-6591 [Electronic] United States
• PMID: 25770171 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: [email protected].

Chemical References

• Antinematodal Agents
• Mebendazole

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Animals
• Antinematodal Agents (administration & dosage, therapeutic use)
• Child
• Child, Preschool
• Disease Outbreaks (prevention & control, statistics & numerical data)
• Female
• Germany (epidemiology)
• Humans
• Male
• Meat (parasitology)
• Mebendazole (administration & dosage, therapeutic use)
• Middle Aged
• Post-Exposure Prophylaxis
• Risk Factors
• Sus scrofa (parasitology)
• Swine
• Trichinellosis (drug therapy, epidemiology, prevention & control, transmission)
• Young Adult