Angiotensin-converting Enzyme Inhibitor Angioedema Requiring Admission to an Intensive Care Unit.

Abstract

OBJECTIVE:

The purpose of this study was to review consecutive cases of angiotensin-converting enzyme (ACE) inhibitor angioedema admitted to an intensive care unit.

METHODS:

Fifty subjects with ACE-inhibitor angioedema admitted from 1998-2011 were reviewed.

RESULTS:

All 50 subjects were men, 62.8 ± 8.4 years of age, 76% African Americans. Fifteen (30%) required ventilatory support and 2 (4%) required tracheostomy. Over half (56%) had taken ACE inhibitors for over a year. Logistic regression identified dyspnea and tongue involvement with the need for ventilatory support (P < .01). Hypercapnia (PaCO2 = 45.2 ± 6.7; P = 0.046) also identified patients needing ventilatory support.

CONCLUSIONS:

Ventilatory support was provided for about one-third of those with ACE inhibitor-associated angioedema. Angioedema can occur even after extended use. Dyspnea and tongue involvement identified patients requiring ventilatory support.

• Authors: Guy W Soo Hoo, Henry K Lin, Imran Junaid, William B Klaustermeyer
• Journal: The American journal of medicine (Am J Med) Vol. 128 Issue 7 Pg. 785-9 (Jul 2015) ISSN: 1555-7162 [Electronic] United States
• PMID: 25770035 (Publication Type: Journal Article)
• Copyright: Published by Elsevier Inc.

Chemical References

• Angiotensin-Converting Enzyme Inhibitors

Topics

• Age Distribution
• Aged
• Angioedema (chemically induced, mortality, therapy)
• Angiotensin-Converting Enzyme Inhibitors (adverse effects, therapeutic use)
• Cohort Studies
• Confidence Intervals
• Critical Care (methods, statistics & numerical data)
• Follow-Up Studies
• Hospital Mortality
• Humans
• Incidence
• Intensive Care Units (statistics & numerical data)
• Logistic Models
• Male
• Middle Aged
• Odds Ratio
• Patient Admission (statistics & numerical data)
• Respiration, Artificial (methods)
• Retrospective Studies
• Risk Assessment
• Severity of Illness Index
• Sex Distribution
• Survival Rate
• Tracheostomy (methods)