Reversible magnetic resonance imaging changes in a case of neuroleptic malignant syndrome.

Abstract

Neuroleptic malignant syndrome (NMS) is a life-threatening neurologic emergency associated with the use of mainly typical antipsychotic drugs. It is characterized by fever, altered mental status, generalized rigidity, autonomic instability, myoclonus, raised creatine phosphokinase, rhabdomyolysis, and leukocytosis. Neuroimaging (brain computed tomography/magnetic resonance imaging [MRI]) is usually normal in most of the cases of NMS. Magnetic resonance imaging findings have not been well elucidated in NMS as yet. Very few cases have been reported worldwide. We herein, report a case of a 42-year-old patient of NMS, who presented to us with reversible changes in MRI brain. This case report highlights the possible MRI changes in NMS and their plausible mechanism.

• Authors: Rajendra Singh Jain, Pankaj Kumar Gupta, Ishwar Dayal Gupta, Rakesh Agrawal, Sunil Kumar, Shankar Tejwani
• Journal: The American journal of emergency medicine (Am J Emerg Med) Vol. 33 Issue 8 Pg. 1113.e1-3 (Aug 2015) ISSN: 1532-8171 [Electronic] United States
• PMID: 25769796 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antipsychotic Agents

Topics

• Adult
• Antipsychotic Agents (adverse effects)
• Brain (pathology)
• Disease Progression
• Humans
• Magnetic Resonance Imaging
• Male
• Neuroleptic Malignant Syndrome (etiology, pathology)
• Schizophrenia (drug therapy)