Abstract |
1. In order to clarify the relative role of catalase (CAT) and glutathione peroxidases (GSH-Px) at normal and high O2 tensions, Rana perezi frogs were chronically treated with aminotriazole (AT), hyperoxia, or both. 2. A 100% survival was observed with both treatments. Hyperoxia increased liver catalase and kidney TBA-RS and decreased GSH-Px. 3. AT caused quantitatively higher alterations than hyperoxia in both organs: CAT was depleted, TBA-RS increased (114% in kidney) and GSH-Px decreased. 4. It is concluded that in Rana perezi (a) CAT, in spite of its much higher KM and Vmax in relation to GSH-Px, is needed to avoid oxidative stress even in normoxia; (b) normoxic tissues have significative amounts of H2O2; (c) GSH-Px does not compensate the lack of CAT.
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Authors | G Barja de Quiroga, M López-Torres, R Pérez-Campo |
Journal | Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology
(Comp Biochem Physiol C Comp Pharmacol Toxicol)
Vol. 94
Issue 2
Pg. 391-8
( 1989)
ISSN: 0742-8413 [Print] England |
PMID | 2576777
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Peroxides
- Thiobarbiturates
- Catalase
- Glutathione Peroxidase
- thiobarbituric acid
- Oxygen
- Amitrole
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Topics |
- Amitrole
(pharmacology)
- Animals
- Catalase
(antagonists & inhibitors, physiology)
- Glutathione Peroxidase
(physiology)
- Kidney
(enzymology)
- Liver
(enzymology)
- Oxidation-Reduction
- Oxygen
(pharmacology)
- Peroxides
(metabolism)
- Ranidae
- Thiobarbiturates
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