HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Inhibitory effects of Saururus chinensis and its components on stomach cancer cells.

Abstract
Saururus chinensis (SC) Baill. (Saururaceae), a perennial herb commonly called Chinese lizard's tail or Sam-baekcho in Korea, has been used in the treatment of edema, gonorrhea, jaundice, and inflammatory diseases. Recently, several reports have been commissioned to examine the anti-cancer activities of this plant. In this study, we evaluated the inhibitory activity and mechanism of action on SC and its components against stomach cancer cells. SC extracts displayed cytotoxic effects on AGS cells in a dose-dependent manner. Moreover, SC increased the number of annexin V-positive apoptotic bodies and phosphorylated JNK and p38 in AGS cells. SC also down-regulated anti-apoptotic (Bcl-2) genes and up-regulated apoptotic (Bax) genes in AGS cells. We further confirmed that caspase activation plays an important role in SC-induced apoptosis in AGS cells. Furthermore, we examined erythro-Austrobailignan-6 and meso-dihydroguaiaretic acid, major active constituents of SC, which induced apoptosis in both the AGS and NCI-N87 stomach cancer cell lines. Taken together, our data provide the evidence that SC and its components induce apoptosis in stomach cancer cells, making it a potential candidate as a chemotherapeutic drug.
AuthorsHa Jin Jeong, Byung-Soo Koo, Tae-Hoon Kang, Heung Mook Shin, Seunghyun Jung, Songhee Jeon
JournalPhytomedicine : international journal of phytotherapy and phytopharmacology (Phytomedicine) Vol. 22 Issue 2 Pg. 256-61 (Feb 15 2015) ISSN: 1618-095X [Electronic] Germany
PMID25765830 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2015 Elsevier GmbH. All rights reserved.
Chemical References
  • Antineoplastic Agents, Phytogenic
  • Plant Extracts
Topics
  • Antineoplastic Agents, Phytogenic (chemistry, pharmacology)
  • Apoptosis (drug effects)
  • Cell Line, Tumor
  • Dose-Response Relationship, Drug
  • Humans
  • Plant Extracts (chemistry, pharmacology)
  • Saururaceae (chemistry)
  • Stomach Neoplasms (metabolism, pathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: