Clinical outcomes of adult inpatients treated with continuous subcutaneous insulin infusion for diabetes mellitus: a systematic review.

Abstract

AIMS:

To provide a systematic review of the current evidence concerning the diabetes-related outcomes of patients provided with continuous subcutaneous insulin infusion for treating diabetes mellitus while a hospital inpatient.

METHODS:

Relevant publications were obtained from MEDLINE and EMBASE databases concerning hospital inpatients with diabetes being treated with continuous subcutaneous insulin infusion. Studies were assessed independently by two reviewers, and data on the following outcomes were extracted: inpatient mortality; clinical complications, e.g. diabetic ketoacidosis; hyperglycaemia; hypoglycaemia; length of hospital stay; mean bedside glucose level; and glucose level on discharge. Obstetric cases were examined separately to look at maternal and neonatal glycaemic outcomes.

RESULTS:

A total of 11 studies met the required criteria and were analysed in detail, 5 of which were predominantly obstetric. No significant complications were reported, with no incidences of death, ketoacidosis or severe hypoglycaemia. Length of hospital stay appeared to be shorter in those patients who remained on continuous subcutaneous insulin infusion, while data on mild hyperglycaemia and hypoglycaemia were inconclusive.

CONCLUSIONS:

There are limited data available to form a significant conclusion about the safety of continuous subcutaneous insulin infusion continuation in hospital; however, its use can be justified with the presence of a specialized inpatient diabetes team for advice and support and an alternative treatment regime (e.g. subcutaneous basal bolus) should be accessible if the need were to arise.

• Authors: J Anstey, A Yassaee, A Solomon
• Journal: Diabetic medicine : a journal of the British Diabetic Association (Diabet Med) Vol. 32 Issue 10 Pg. 1279-88 (Oct 2015) ISSN: 1464-5491 [Electronic] England
• PMID: 25763540 (Publication Type: Journal Article, Review, Systematic Review)
• Copyright: © 2015 The Authors. Diabetic Medicine © 2015 Diabetes UK.

Chemical References

• Blood Glucose
• Hypoglycemic Agents
• Insulin

Topics

• Adult
• Blood Glucose (drug effects, metabolism)
• Diabetes Mellitus, Type 1 (complications, drug therapy, epidemiology)
• Female
• Humans
• Hypoglycemic Agents (administration & dosage)
• Infusions, Subcutaneous
• Inpatients (statistics & numerical data)
• Insulin (administration & dosage)
• Insulin Infusion Systems
• Length of Stay (statistics & numerical data)
• Male
• Pregnancy
• Pregnancy in Diabetics (drug therapy, epidemiology)
• Treatment Outcome