Enteral topiramate in a pediatric patient with refractory status epilepticus: a case report and review of the literature.

Abstract

We describe the use of topiramate in a healthy 12-year-old (88-kg) male who developed refractory generalized convulsive status epilepticus. Seizures persisted despite aggressive use of benzodiazepines (intravenous lorazepam; oral clorazepate), barbiturates (i.e., phenobarbital, pentobarbital), and hydantoins. The child's seizures were controlled with nasogastrically administered topiramate in doses up to 500 mg twice daily (11.4 mg/kg/day). The patient did not display any clinical or laboratory signs of metabolic acidosis while receiving topiramate. Topiramate should be considered as a treatment option in refractory status epilepticus.

• Authors: Chasity M Shelton, Elizabeth L Alford, Stephanie Storgion, James Wheless, Stephanie J Phelps
• Journal: The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG (J Pediatr Pharmacol Ther) 2014 Oct-Dec Vol. 19 Issue 4 Pg. 317-24 ISSN: 1551-6776 [Print] United States
• PMID: 25762878 (Publication Type: Case Reports)