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An adenosine A3 receptor agonist inhibits DSS-induced colitis in mice through modulation of the NF-κB signaling pathway.

Abstract
The role of the adenosine A3 receptor (A3AR) in experimental colitis is controversial. The A3AR agonist N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide (IB-MECA) has been shown to have a clinical benefit, although studies in A3AR-deficient mice suggest a pro-inflammatory role. However, there are no studies on the effect of 2-Cl-IB-MECA and the molecular mechanism of action of A3AR in murine colitis models in vivo. Is it the same as that observed in vitro? The interaction between 2-CL-IB-MECA and A3AR in a murine colitis model and the signaling pathways associated with this interaction remain unclear. Here we demonstrate a role for the NF-κB signaling pathway and its effect on modifying the activity of proinflammatory factors in A3AR-mediated biological processes. Our results demonstrated that A3AR activation possessed marked effects on experimental colitis through the NF-κB signaling pathway.
AuthorsTianhua Ren, Ting Tian, Xiao Feng, Shicai Ye, Hao Wang, Weiyun Wu, Yumei Qiu, Caiyuan Yu, Yanting He, Juncheng Zeng, Junwei Cen, Yu Zhou
JournalScientific reports (Sci Rep) Vol. 5 Pg. 9047 (Mar 12 2015) ISSN: 2045-2322 [Electronic] England
PMID25762375 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Adenosine A3 Receptor Agonists
  • Cytokines
  • Inflammation Mediators
  • NF-kappa B
  • Receptor, Adenosine A3
  • Peroxidase
  • Adenosine
  • 2-chloro-N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide
Topics
  • Adenosine (administration & dosage, analogs & derivatives, pharmacology)
  • Adenosine A3 Receptor Agonists (administration & dosage, pharmacology)
  • Animals
  • Colitis (chemically induced, drug therapy, metabolism, pathology)
  • Cytokines (genetics, metabolism)
  • Disease Models, Animal
  • Gene Expression
  • Inflammation Mediators (metabolism)
  • Intestinal Mucosa (drug effects, metabolism, pathology)
  • Mice
  • NF-kappa B (metabolism)
  • Peroxidase (metabolism)
  • Receptor, Adenosine A3 (genetics, metabolism)
  • Signal Transduction (drug effects)

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