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Evaluation of the therapeutic effect of transdermal beta-blocker therapy in patients with essential hypertension.

Abstract
Transdermal drug delivery has been applied to various agents in an effort to decrease the frequency of drug administration and improvement of the patients compliance. In the present study, it could be demonstrated that transdermal monotherapy (BIO TSD) with a beta-blocker (20 mg mepindolol) in patients with essential hypertension led to an effective 24 h blood pressure lowering effect within 1 week (160.1 +/- 6.1 mmHg/95.8 +/- 8.3 mmHg vs. 136.8 +/- 7.2 mmHg/84.3 +/- 5.0 mmHg; p less than 0.05). Also a reduction of excessive blood pressure peaks in the circadian blood pressure profiles was observed. Studies comparing transdermal with oral beta-blocker administration in hypertensive patients would further substantiate the value of this new therapeutic system as an antihypertensive treatment.
AuthorsC Spieker, W Vetter, W Zidek, H Vetter
JournalArzneimittel-Forschung (Arzneimittelforschung) Vol. 39 Issue 11A Pg. 1512-4 (Nov 1989) ISSN: 0004-4172 [Print] Germany
PMID2576202 (Publication Type: Journal Article)
Chemical References
  • Adrenergic beta-Antagonists
  • mepindolol
  • Pindolol
Topics
  • Administration, Cutaneous
  • Adrenergic beta-Antagonists (administration & dosage, therapeutic use)
  • Adult
  • Blood Pressure (drug effects)
  • Electrocardiography
  • Female
  • Humans
  • Hypertension (drug therapy, physiopathology)
  • Male
  • Pindolol (administration & dosage, analogs & derivatives, therapeutic use)

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