The effect of monoamine depletors on metrazol induced convulsions and brain gamma-aminobutyric acid (GABA) contents in rats.

Abstract

The thresholds for metrazol (pentylenetetrazol) clonic convulsions and brain gamma-aminobutyric acid contents were significantly reduced after treatment with the monoamine depletors reserpine, tetrabenazine and p-chlorophenylalanine. Moreover, alpha-methyltyrosine, and alpha-methyl-m-tyrosine also lowered metrazol threshold seizures, but had no effect on brain alpha-aminobutyric acid contents. Furthermore, neither 5-hydroxytryptophan nor tranylcypromine had a significant effect on metrazol threshold seizures or brain alpha-aminobutyric acid contents, but blocked the changes previously induced by p-chlorophenyl alanine and reserpine.

• Authors: W T Abed
• Journal: The Journal of pharmacy and pharmacology (J Pharm Pharmacol) Vol. 41 Issue 11 Pg. 807-8 (Nov 1989) ISSN: 0022-3573 [Print] England
• PMID: 2576059 (Publication Type: Journal Article)

Chemical References

• Anticonvulsants
• Biogenic Monoamines
• gamma-Aminobutyric Acid
• Pentylenetetrazole

Topics

• Animals
• Anticonvulsants
• Biogenic Monoamines (metabolism)
• Brain (drug effects, metabolism)
• Female
• Male
• Pentylenetetrazole
• Rats
• Rats, Inbred Strains
• Seizures (chemically induced, physiopathology, prevention & control)
• gamma-Aminobutyric Acid (metabolism)