The pre-BCR to the rescue: therapeutic targeting of pre-B cell ALL.

Abstract

Pre B-ALL is an aggressive cancer of the blood for which treatment of patients with relapsed and refractory disease remains a challenge. In this issue of Cancer Cell, Geng and colleagues surveyed the activation status of the pre-B cell receptor and comprehensively investigated downstream signaling mechanisms currently targetable with small molecule inhibitors.

• Authors: Thomas Trimarchi, Iannis Aifantis
• Journal: Cancer cell (Cancer Cell) Vol. 27 Issue 3 Pg. 321-3 (Mar 09 2015) ISSN: 1878-3686 [Electronic] United States
• PMID: 25759017 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Comment)
• Copyright: Copyright © 2015 Elsevier Inc. All rights reserved.

Chemical References

• BCL6 protein, human
• DNA-Binding Proteins
• Proto-Oncogene Proteins c-bcl-6

Topics

• DNA-Binding Proteins (physiology)
• Gene Expression Regulation, Neoplastic
• Humans
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (metabolism)
• Precursor Cells, B-Lymphoid (metabolism)
• Proto-Oncogene Proteins c-bcl-6