Circadian systems biology in Metazoa.
|
| Abstract |
Systems biology, which can be defined as integrative biology, comprises multistage processes that can be used to understand components of complex biological systems of living organisms and provides hierarchical information to decoding life. Using systems biology approaches such as genomics, transcriptomics and proteomics, it is now possible to delineate more complicated interactions between circadian control systems and diseases. The circadian rhythm is a multiscale phenomenon existing within the body that influences numerous physiological activities such as changes in gene expression, protein turnover, metabolism and human behavior. In this review, we describe the relationships between the circadian control system and its related genes or proteins, and circadian rhythm disorders in systems biology studies. To maintain and modulate circadian oscillation, cells possess elaborative feedback loops composed of circadian core proteins that regulate the expression of other genes through their transcriptional activities. The disruption of these rhythms has been reported to be associated with diseases such as arrhythmia, obesity, insulin resistance, carcinogenesis and disruptions in natural oscillations in the control of cell growth. This review demonstrates that lifestyle is considered as a fundamental factor that modifies circadian rhythm, and the development of dysfunctions and diseases could be regulated by an underlying expression network with multiple circadian-associated signals.
|
|---|---|
| Authors | Li-Ling Lin, Hsuan-Cheng Huang, Hsueh-Fen Juan, 2014 Taida Cancer Systems Biology Study Group |
| Journal | Briefings in bioinformatics (Brief Bioinform) Vol. 16 Issue 6 Pg. 1008-24 (Nov 2015) ISSN: 1477-4054 [Electronic] England |
| PMID | 25758249 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review) |
| Copyright | © The Author 2015. Published by Oxford University Press. For Permissions, please email: [email protected]. |
| Topics |
|
Join CureHunter, for free Research Interface BASIC access!
Realize the full power of the drug-disease research graph!