Protective effects of edaravone combined puerarin on inhalation lung injury induced by black gunpowder smog.

Abstract

OBJECTIVE:

The present study aimed to investigate the combined effects of puerarin with edaravone on inhalation lung injury induced by black gunpowder smog.

MATERIALS AND METHODS:

Male Wistar rats were divided into five groups (control group, edaravone group, puerarin group, edaravone combined with puerarin group and inhalation group). The severity of pulmonary injuries was evaluated after inducing acute lung injury. Arterial blood gas, inflammatory cytokines, biochemical, parameters, cell counting, W/D weight ratio and histopathology were analyzed. Results in lung tissues, either edaravone or puerarin treatment alone showed significant protective effects against neutrophil infiltration and tissue injury, as demonstrated by myeloperoxidase activity and histopathological analysis (all p<0.05). In addition, combined treatment with both edaravone and puerarin demonstrated additive protective effects on smog-induced lung injury, compared with single treatment.

CONCLUSIONS:

Combination of edaravone and puerarin shows promise as a new treatment option for acute lung injury/acute respiratory distress syndrome patients.

• Authors: Zhengguan Wang, Ruibing Li, Yifan Liu, Xiaoting Liu, Wenyan Chen, Shumin Xu, Yuni Guo, Jinyang Duan, Yihong Chen, Chengbin Wang
• Journal: International immunopharmacology (Int Immunopharmacol) Vol. 26 Issue 1 Pg. 125-32 (May 2015) ISSN: 1878-1705 [Electronic] Netherlands
• PMID: 25754765 (Publication Type: Journal Article)
• Copyright: Copyright © 2015 Elsevier B.V. All rights reserved.

Chemical References

• Isoflavones
• Smog
• Edaravone
• Antipyrine
• puerarin

Topics

• Animals
• Antipyrine (administration & dosage, analogs & derivatives, therapeutic use)
• Bronchoalveolar Lavage Fluid (chemistry, cytology)
• Disease Models, Animal
• Drug Therapy, Combination
• Edaravone
• Inhalation Exposure (adverse effects)
• Isoflavones (administration & dosage, therapeutic use)
• Lung (drug effects, immunology, pathology)
• Lung Injury (chemically induced, immunology, prevention & control)
• Male
• Organ Size (drug effects)
• Rats, Wistar
• Smog (adverse effects, analysis)