Abstract | BACKGROUND: PATIENTS AND METHODS: RESULTS: After one month of therapy on vismodegib, there were significant reductions in the size of multiple BCCs on the patient's face. The patient remains on this therapy. CONCLUSION: Hedgehog pathway inhibition is an effective strategy to treat unresectable BCCs from Gorlin-Goltz syndrome. Although vismodegib shows some promising clinical results in the early phase of its use, there are concerns of possible resistance developing within months. Duration of therapy, role of maintenance treatment and drug modification to reduce resistance need to be explored in future case studies.
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Authors | Fidelis O Ojevwe, Cindy D Ojevwe, James P Zacny, Arkadiusz Z Dudek, Amy Lin, Patrick Kohlitz |
Journal | Anticancer research
(Anticancer Res)
Vol. 35
Issue 3
Pg. 1777-81
(Mar 2015)
ISSN: 1791-7530 [Electronic] Greece |
PMID | 25750342
(Publication Type: Case Reports, Journal Article)
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Copyright | Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved. |
Chemical References |
- Anilides
- HhAntag691
- Pyridines
|
Topics |
- Adult
- Anilides
(therapeutic use)
- Basal Cell Nevus Syndrome
(drug therapy, pathology)
- Humans
- Male
- Pyridines
(therapeutic use)
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