Phosphatidylserine-specific phospholipase A1 (PS-PLA1) expression in colorectal cancer correlates with tumor invasion and hematogenous metastasis.

Abstract

BACKGROUND:

The function of phosphatidylserine-specific phospholipase A1 (PS-PLA1), a phospholipase that acts specifically on phosphatidylserine and produces lysophosphatidylserine, a lysophospholipid mediator, has not been fully elucidated. We evaluated the role of PS-PLA1 in oncogenesis and metastasis of colorectal cancer (CRC).

MATERIALS AND METHODS:

Specimens from 85 patients with CRC were immunostained with a monoclonal antibody against PS-PLA1. The correlation between PS-PLA1 expression and the clinicopathological variables was analyzed.

RESULTS:

Tumor depth and hematogenous metastasis independently positively correlated with PS-PLA1 expression. High PS-PLA1 expression was associated with shorter disease-free survival, although it was not an independent predictive factor.

CONCLUSION:

PS-PLA1 expression in CRC is associated with tumor invasion and metastasis.

• Authors: Yuuki Iida, Eiji Sunami, Hiroharu Yamashita, Masaya Hiyoshi, Soichiro Ishihara, Hironori Yamaguchi, Asuka Inoue, Kumiko Makide, Nelson H Tsuno, Junken Aoki, Joji Kitayama, Toshiaki Watanabe
• Journal: Anticancer research (Anticancer Res) Vol. 35 Issue 3 Pg. 1459-64 (Mar 2015) ISSN: 1791-7530 [Electronic] Greece
• PMID: 25750298 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

Chemical References

• Phosphatidylserines
• Phospholipases A1

Topics

• Aged
• Colorectal Neoplasms (enzymology, pathology)
• Disease-Free Survival
• Female
• Humans
• Male
• Middle Aged
• Neoplasm Invasiveness
• Neoplasm Metastasis
• Neoplastic Cells, Circulating
• Phosphatidylserines (metabolism)
• Phospholipases A1 (analysis, physiology)