Abstract | OBJECTIVE: METHODS & RESULTS: We performed acetylcholine (ACh) spasm provocation tests over a period of 22 years (1991-2012) among 1,440 patients, including 981 IHD and 459 non-IHD subjects. A total of 43 patients with significant organic stenosis were excluded, and the remaining 416 patients with non-IHD or non-ob-CAD disease were assessed. ACh was injected in incremental doses of 20/50/80 μg into the right coronary artery (RCA) and 20/50/100/(200) μg into the left coronary artery (LCA). Positive coronary spasms were defined as transient luminal narrowing of >99%. Positive coronary spasms were noted in 17.3% of the non-IHDs patients (72/416), compared to 11.4% (15/132), 19% (8/42), 16.7% (5/30), 23.9% (16/67), and 19.3% (28/145), in the patients in the Aty, Val, HCM, CHF, and Oth groups, respectively. The rate of positive provoked spasms was higher in men than women, although not significantly [20.6% (46/223) vs. 13.4% (26/193), ns], and significantly higher in the late period (2001-2012) than in the early period (1991-2000) (36.8% vs. 7.0%, p<0.001). CONCLUSION: Physicians should perform spasm provocation tests in patients with IHD as well as non-IHD with non-ob-CAD, as one of six non-IHD patients in this study exhibited provoked coronary spasms.
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Authors | Shozo Sueda, Toru Miyoshi, Yasuhiro Sasaki, Tomoki Sakaue, Hirokazu Habara, Hiroaki Kohno |
Journal | Internal medicine (Tokyo, Japan)
(Intern Med)
Vol. 54
Issue 3
Pg. 281-6
( 2015)
ISSN: 1349-7235 [Electronic] Japan |
PMID | 25748736
(Publication Type: Journal Article)
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Chemical References |
- Cholinergic Agonists
- Acetylcholine
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Topics |
- Acetylcholine
(administration & dosage)
- Aged
- Chest Pain
(diagnostic imaging)
- Cholinergic Agonists
(administration & dosage)
- Coronary Angiography
- Coronary Vasospasm
(chemically induced, diagnostic imaging, physiopathology)
- Coronary Vessels
(drug effects)
- Dose-Response Relationship, Drug
- Female
- Heart Diseases
(diagnostic imaging, physiopathology)
- Humans
- Injections, Intra-Arterial
- Male
- Middle Aged
- Muscle, Smooth, Vascular
(drug effects)
- Retrospective Studies
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