Recent studies have investigated the expression of proliferative markers, but little is known about the expression of
cytokeratin 15 and 19 in different histological subtypes of
basal cell carcinoma (BCC). We conducted cellular,
biological, clinicopathological and immunohistochemical analysis on the manifestations of 8 BCC by
hematoxylin and
eosin stain (H&E) staining and immunohistochemistry and reviewed relevant literature. Microscopically, the
tumor cells were multiple remarkable foci of
epidermolytic hyperkeratosis with large pleomorphic nuclei and scant cytoplasm together with peripheral palisading and forming solid nests. Furthermore, the most
tumors were composed of highly cellular areas with a homogenous population of round, ovoid and spindle cells, hyperchromatic nuclei, high cellular pleomorphism, high mitotic index and various morphologic patterns. Moreover, the
tumors displayed an invasive growth, with positive expression of
Cytokeratin 19 (CK19) and negative expression of CK15. Our study revealed that the expression of CK19 was associated with progression and invasion in cases with BCC and immunohistochemistry is indispensable in distinguishing this
tumor from other types of cutaneous
carcinoma. To our best knowledge, it may be a considerable
biomarker to assess invasiveness of cutaneous-surface BCC and to guide clinical management of such
tumors.