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Development of an acid ceramidase activity-based probe.

Abstract
Acid ceramidase is responsible for the ultimate step in the catabolism of (glyco)sphingolipids by hydrolysis of ceramide into sphingosine and free fatty acid. Deficiency in acid ceramidase is the molecular basis of Farber disease. Here we report the synthesis and characterization of an activity-based acid ceramidase probe.
AuthorsCécile M J Ouairy, Maria J Ferraz, Rolf G Boot, Marc P Baggelaar, Mario van der Stelt, Monique Appelman, Gijsbert A van der Marel, Bogdan I Florea, Johannes M F G Aerts, Herman S Overkleeft
JournalChemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 51 Issue 28 Pg. 6161-3 (Apr 11 2015) ISSN: 1364-548X [Electronic] England
PMID25748248 (Publication Type: Journal Article)
Chemical References
  • Ceramides
  • Fatty Acids
  • Molecular Probes
  • Sphingolipids
  • Acid Ceramidase
  • Sphingosine
Topics
  • Acid Ceramidase (analysis, metabolism)
  • Ceramides (chemistry, metabolism)
  • Enzyme Activation
  • Fatty Acids (chemistry, metabolism)
  • Hydrolysis
  • Molecular Probes (chemical synthesis, chemistry, metabolism)
  • Molecular Structure
  • Sphingolipids (chemistry, metabolism)
  • Sphingosine (chemistry, metabolism)

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