Prevalence and associations of erectile dysfunction in a sample of Italian males with type 2 diabetes.

Abstract

AIM:

The aim of this study was to evaluate the prevalence of erectile dysfunction (ED) in a sample of type 2 diabetic patients. As secondary endpoint, we evaluated the levels of some adipocytokines in patients with and without ED.

MATERIAL AND METHODS:

We enrolled 220 males affected by type 2 diabetes mellitus. We administered the IIEF (International Index of Erectile Function), SAS (self-rating anxiety scale) and SDS (self-rating depression scale) questionnaires. We evaluated body mass index, glycemic control, fasting plasma insulin (FPI), homeostasis model assessment of insulin resistance index (HOMA-IR), lipid profile, sexual hormones, adiponectin (ADN), resistin, retinol binding protein-4 (RBP-4), visfatin, vaspin.

RESULTS:

52.9% of patients were affected by ED. Patients with a HbA1c <7% (53 mmol/mol) in all measurements in the two previous years had a lower incidence of ED, while the prevalence of ED increased with the increasing of times HbA1c was >7% (53 mmol/mol). Patients with ED had higher levels of triglycerides, and higher levels of FPI, 9.9 μU/ml vs 8.2 μU/ml (p<0.05). Resistin levels were higher in patients with ED compared to those without ED (p<0.05) and free testosterone was lower in patients affected by ED.

CONCLUSIONS:

Almost half of type 2 diabetic patients attending our clinic were affected by ED and glycemic control seems to play a role in ED pathogenesis.

• Authors: Giuseppe Derosa, Davide Romano, Carmine Tinelli, Angela D'Angelo, Pamela Maffioli
• Journal: Diabetes research and clinical practice (Diabetes Res Clin Pract) Vol. 108 Issue 2 Pg. 329-35 (May 2015) ISSN: 1872-8227 [Electronic] Ireland
• PMID: 25747572 (Publication Type: Journal Article, Observational Study, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Blood Glucose
• Testosterone

Topics

• Adult
• Aged
• Blood Glucose (metabolism)
• Cross-Sectional Studies
• Diabetes Mellitus, Type 2 (blood, complications, epidemiology)
• Erectile Dysfunction (blood, epidemiology, etiology)
• Humans
• Insulin Resistance
• Italy (epidemiology)
• Male
• Middle Aged
• Prevalence
• Testosterone (blood)