Abstract | AIMS: METHODS AND RESULTS: Our experiments exhibited that gas exchange dysfunction and lung tissue inflammation were observed in animals exposed to CLP. Hydrogen-rich saline treatment significantly attenuated lung injury as indicated by significantly improved gas exchange and histological changes in the lung and significantly reduced lung water content (LWC) and neutrophil infiltration 8h after CLP. Lipid peroxidation and DNA oxidation in the lung tissue were significantly reduced along with a decreased nitrotyrosine content and maintained superoxide dismutase activity in the presence of hydrogen, demonstrating antioxidant role of hydrogen in CLP-induced ALI. Importantly, hydrogen-rich saline treatment significantly inhibited the activation of p-p38 and NF-κB while suppressing the production of several proinflammatory mediators. CONCLUSIONS:
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Authors | Yu Zhai, Xiaohong Zhou, Qingchun Dai, Yamin Fan, Xinli Huang |
Journal | Experimental and molecular pathology
(Exp Mol Pathol)
Vol. 98
Issue 2
Pg. 268-76
(Apr 2015)
ISSN: 1096-0945 [Electronic] Netherlands |
PMID | 25746665
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Copyright | Copyright © 2015 Elsevier Inc. All rights reserved. |
Chemical References |
- Anti-Inflammatory Agents
- Antioxidants
- NF-kappa B
- Sodium Chloride
- Hydrogen
- DNA
- Superoxide Dismutase
- p38 Mitogen-Activated Protein Kinases
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Topics |
- Acute Lung Injury
(drug therapy)
- Animals
- Anti-Inflammatory Agents
(pharmacology)
- Antioxidants
(pharmacology)
- Cecum
(surgery)
- DNA
(metabolism)
- Disease Models, Animal
- Enzyme Activation
(drug effects)
- Hydrogen
(pharmacology)
- Lipid Peroxidation
(drug effects)
- Lung
(pathology)
- Male
- NF-kappa B
(antagonists & inhibitors, metabolism)
- Neutrophil Infiltration
(drug effects)
- Oxidation-Reduction
(drug effects)
- Punctures
- Rats
- Rats, Sprague-Dawley
- Sepsis
- Sodium Chloride
(pharmacology)
- Superoxide Dismutase
(metabolism)
- p38 Mitogen-Activated Protein Kinases
(antagonists & inhibitors, metabolism)
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