Bone muscle interactions and vitamin D.

Abstract

Beyond the established roles of vitamin D in bone and mineral homeostasis, we are becoming increasingly aware of its diverse effects in skeletal muscle. Subjects with severe vitamin D deficiency or mutations of the vitamin D receptor develop generalized atrophy of muscle and bone, suggesting coordinated effects of vitamin D in musculoskeletal physiology. At a mechanistic level, vitamin D exerts wide-ranging effects in muscle and bone calcium handling, differentiation and development. Vitamin D also modulates muscle and bone-derived hormones, facilitating cross-talk between these tissues. In this review, we discuss emerging evidence that vitamin D regulates bone and muscle in a direct, integrated fashion, positioning the vitamin D pathway as a potential therapeutic target for musculoskeletal diseases. This article is part of a Special Issue entitled "Muscle Bone Interactions".

• Authors: Jenny E Gunton, Christian M Girgis, Paul A Baldock, Paul Lips
• Journal: Bone (Bone) Vol. 80 Pg. 89-94 (Nov 2015) ISSN: 1873-2763 [Electronic] United States
• PMID: 25745883 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2015 Elsevier Inc. All rights reserved.

Chemical References

• Vitamin D

Topics

• Animals
• Bone and Bones (metabolism)
• Humans
• Muscle, Skeletal (metabolism)
• Osteoporosis (metabolism)
• Sarcopenia (metabolism)
• Vitamin D (metabolism)