Antiproliferative effect of valproic acid and 5,7-dimethoxycoumarin against A2058 human melanoma cells.

Abstract

Melanoma is one of the most malignant tumors of a dangerous high incidence and high metastatic potential. It grows quickly and in an advanced stage is resistant to radio-, chemo- and immunotherapy, which makes it difficult to cure. Therefore, research efforts are focused on the development of new therapeutics or chemopreventive strategies. The aim of the study was to investigate whether the valproic acid and 5,7-dimethoxycoumarin have an antiproliferative activity against A2058 human melanoma cell line. Investigated compounds inhibited the proliferation of cells, however, no synergistic effect of their co-administration was observed.

• Authors: Daniel Wolny, Ewa Chodurek, Zofia Dzierzewicz
• Journal: Acta poloniae pharmaceutica (Acta Pol Pharm) 2014 Nov-Dec Vol. 71 Issue 6 Pg. 1056-9 ISSN: 0001-6837 [Print] Poland
• PMID: 25745779 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anticarcinogenic Agents
• Coumarins
• Valproic Acid
• 5,7-dimethoxycoumarin

Topics

• Anticarcinogenic Agents (administration & dosage, pharmacology)
• Cell Culture Techniques
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Coumarins (administration & dosage, pharmacology)
• Dose-Response Relationship, Drug
• Drug Synergism
• Humans
• Melanoma (pathology)
• Molecular Structure
• Valproic Acid (administration & dosage, pharmacology)