Abstract | BACKGROUND: OBJECTIVE: METHODS: RESULTS: The mean Hp levels among the studied groups were as follows; 8.02 ± 0.93 (mg/dl), 8.6 ±0.72 (mg/dl) and 122 ± 18.5(mg/dl) for TM, TI and the controls respectively. Both patient groups had significantly lower Hp level compared to the controls (P<0.0001) with significant lower level in TM compared to TI children ( P= 0.034). Significant inverse correlations were found between serum Hp and sTfR levels ( reflecting the erythropoietic activity) in thalassemia children combined and in each group (TM and TI) as well as among HCV infected children. STfR was the only significant independent predictor for serum Hp level (t= -5.585, P<0.0001). Among HCV infected patients, no significant correlation was found between serum Hp and serum transaminases. CONCLUSION: Serum Hp depletion in thalassemia had significant relation to disease severity and correlated well with their erythropoietic activity, as assessed by the measurement of sTfR without significant relation to HCV infection. Extensive multicenter studies are recommended.
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Authors | Seham M Ragab, Manal A Safan, Eman A Badr |
Journal | Mediterranean journal of hematology and infectious diseases
(Mediterr J Hematol Infect Dis)
Vol. 7
Issue 1
Pg. e2015019
( 2015)
ISSN: 2035-3006 [Print] Italy |
PMID | 25745546
(Publication Type: Journal Article)
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