P-selectin and subclinical and clinical atherosclerosis: the Multi-Ethnic Study of Atherosclerosis (MESA).

Abstract

OBJECTIVE:

P-selectin is a cellular adhesion molecule that has been shown to be crucial in development of coronary heart disease (CHD). We sought to determine the role of P-selectin on the risk of atherosclerosis in a large multi-ethnic population.

METHODS:

Data from the Multi-Ethnic Study of Atherosclerosis (MESA), including 1628 African, 702 Chinese, 2393 non-Hispanic white, and 1302 Hispanic Americans, were used to investigate the association of plasma P-selectin with CHD risk factors, coronary artery calcium (CAC), intima-media thickness, and CHD. Regression models were used to investigate the association between P-selectin and risk factors, Tobit model for CAC, and Cox regression for CHD events.

RESULTS:

Mean levels of P-selectin differed by ethnicity and were higher in men (P<0.001). For all ethnic groups, P-selectin was positively associated with measures of adiposity, blood pressure, current smoking, LDL, and triglycerides and inversely with HDL. A significant ethnic interaction was observed for the association of P-selectin and prevalent diabetes; however, P-selectin was positively associated with HbA1c in all groups. Higher P-selectin levels were associated with greater prevalence of CAC. Over 10.1 years of follow-up, there were 335 incident CHD events. There was a positive linear association between P-selectin levels and rate of incident CHD after adjustment for traditional risk factors. However, association was only significant in non-Hispanic white Americans (HR: 1.81, 95% CI 1.07 to 3.07, P=0.027).

CONCLUSION:

We observed ethnic heterogeneity in the association of P-selectin and risk of CHD.

• Authors: Suzette J Bielinski, Cecilia Berardi, Paul A Decker, Phillip S Kirsch, Nicholas B Larson, James S Pankow, Michele Sale, Mariza de Andrade, Hugues Sicotte, Weihong Tang, Naomi Q Hanson, Christina L Wassel, Joseph F Polak, Michael Y Tsai
• Journal: Atherosclerosis (Atherosclerosis) Vol. 240 Issue 1 Pg. 3-9 (May 2015) ISSN: 1879-1484 [Electronic] Ireland
• PMID: 25744700 (Publication Type: Comparative Study, Journal Article, Multicenter Study, Research Support, N.I.H., Extramural)
• Copyright: Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Biomarkers
• P-Selectin
• SELP protein, human

Topics

• Black or African American
• Aged
• Aged, 80 and over
• Asian
• Asymptomatic Diseases
• Biomarkers (blood)
• Carotid Artery Diseases (blood, diagnosis, ethnology)
• Carotid Intima-Media Thickness
• Coronary Angiography
• Coronary Artery Disease (blood, diagnosis, ethnology)
• Female
• Hispanic or Latino
• Humans
• Incidence
• Kaplan-Meier Estimate
• Linear Models
• Male
• Middle Aged
• P-Selectin (blood)
• Predictive Value of Tests
• Proportional Hazards Models
• Risk Factors
• Sex Factors
• United States (epidemiology)
• Vascular Calcification (blood, diagnosis, ethnology)
• White People