HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Survivin suppressor (YM155) enhances chemotherapeutic efficacy against canine histiocytic sarcoma in murine transplantation models.

Abstract
Histiocytic sarcoma (HS) in dogs exhibits aggressive clinical and biological behavior. Currently, no effective treatments are available for dogs with HS. Survivin, a member of a family of apoptosis protein inhibitors, could serve as a potential therapeutic target in several canine cancers. Sepantronium bromide (YM155) has recently been established as a novel survivin-targeting agent. The aim of this study was to use YM155 as a tool for evaluating survivin-targeted therapies against dogs with HS, and to investigate how YM155 treatment affects antitumor and chemotherapeutic efficacies in murine xenograft models using canine HS cells. The results showed that in HS cells with lomustine (CCNU) resistance, YM155 treatment suppressed both the cell-growth potential and cell resistance to CCNU, which essentially increases the chemotherapy efficacy in the murine models. The evidence presented here supports the favorable preclinical evaluation that survivin-targeted therapies might be effective against HS in dogs.
AuthorsHiroki Yamazaki, Satoshi Takagi, Kenji Hosoya, Masahiro Okumura
JournalResearch in veterinary science (Res Vet Sci) Vol. 99 Pg. 137-44 (Apr 2015) ISSN: 1532-2661 [Electronic] England
PMID25744435 (Publication Type: Journal Article)
CopyrightCopyright © 2015 Elsevier Ltd. All rights reserved.
Chemical References
  • Antineoplastic Agents
  • Birc5 protein, mouse
  • Imidazoles
  • Inhibitor of Apoptosis Proteins
  • Naphthoquinones
  • Repressor Proteins
  • Survivin
  • sepantronium
Topics
  • Animals
  • Antineoplastic Agents (therapeutic use)
  • Cell Line, Tumor
  • Dog Diseases (drug therapy, etiology)
  • Dogs
  • Histiocytic Sarcoma (drug therapy, etiology, veterinary)
  • Imidazoles (therapeutic use)
  • Inhibitor of Apoptosis Proteins (antagonists & inhibitors)
  • Mice
  • Models, Animal
  • Naphthoquinones (therapeutic use)
  • Repressor Proteins (antagonists & inhibitors)
  • Survivin

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: