Abstract | OBJECTIVE: METHODS: The retrospective cohort study was performed on clinical and pathological data of 18 DSCRT patients. Among them, two subgroups were classified according to treatment modalities. 10 cases underwent operation and adjuvant chemotherapy (group 1, 10/18, 55.6%) and 8 cases were diagnosed by fine needle aspiration biopsy without surgical intervention (group 2, 8/18, 44.4%). All cases received six courses of multiple agents chemotherapy. RESULTS: All cases were histologically confirmed as DSRCT and Cox regression revealed that sex, tumor localization and treatment modality affected patient outcomes. Kaplan-Meier analysis revealed that the median survival time was 22.0 ± 4.0 mo in group 1 versus 9.0 ± 0.7 mo in group 2. CONCLUSION: DSRCT is highly aggressive malignance with poor prognosis, surgical excision with combination of chemotherapy can significantly improve the survival outcomes.
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Authors | Yuhong Tang, Hualin Song, Yali Bao, Yang Zhi |
Journal | International journal of surgery (London, England)
(Int J Surg)
Vol. 16
Issue Pt A
Pg. 49-54
(Apr 2015)
ISSN: 1743-9159 [Electronic] England |
PMID | 25743388
(Publication Type: Journal Article)
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Copyright | Copyright © 2015 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved. |
Topics |
- Abdominal Neoplasms
(diagnosis, mortality, therapy)
- Adolescent
- Adult
- Child
- China
(epidemiology)
- Combined Modality Therapy
- Desmoplastic Small Round Cell Tumor
(diagnosis, mortality, therapy)
- Female
- Follow-Up Studies
- Humans
- Kaplan-Meier Estimate
- Male
- Middle Aged
- Neoplasm Staging
- Pelvic Neoplasms
(diagnosis, mortality, therapy)
- Prognosis
- Retrospective Studies
- Survival Rate
(trends)
- Young Adult
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