[A case of renal salt-wasting syndrome during chemotherapy for advanced gastric cancer].

Abstract

A 66-year-old woman was admitted to our hospital with heartburn and liver dysfunction. She was diagnosed with advanced gastric cancer. After the initiation of chemotherapy with trastuzumab, capecitabine, and cisplatin, she developed hyponatremia and renal failure with renal salt-wasting syndrome (RSWS). She recovered from these conditions after infusion of hypertonic saline. A diagnosis of RSWS should be considered in patients with hyponatremia who receive cisplatin-based chemotherapy.

• Authors: Hisae Yasuhara, Atsushi Imagawa, Nao Koike, Eijiro Ueta, Akihiro Matsumi, Hiroyuki Terasawa, Hiroyuki Sakae, Keiko Takeuchi, Manabu Fujihara, Hitomi Endo, Hideki Jinno, Akio Moriya, Hidenori Hata, Morihito Nakatsu, Masaharu Ando
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 42 Issue 2 Pg. 225-7 (Feb 2015) ISSN: 0385-0684 [Print] Japan
• PMID: 25743144 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Sodium
• Cisplatin

Topics

• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Cisplatin (administration & dosage, adverse effects)
• Female
• Humans
• Kidney Diseases (chemically induced)
• Liver Neoplasms (drug therapy, secondary)
• Sodium (blood)
• Stomach Neoplasms (drug therapy, pathology)