[A comparative evaluation of the efficacy of sucralfate and H2-histamine blockaders in treating peptic ulcer].

Abstract

Sucralfate (55 patients), cimetidine (25 patients), ranitidine (30 patients), antacids and cholinolytics (32 patients) were studied and compared in open clinical trials for the efficacy in the treatment of ulcer disease of the stomach and duodenum. During 5 weeks, ulcers completely healed in 100% of the patients given sucralfate (in 94.5% for 4 weeks), in 90% of the patients treated with ranitidine, in 84% on cimetidine, and in 78% of the patients undergoing treatment with antacids and cholinolytics.

• Authors: V T Ivashkin, E I Tkachenko, V B Grinevich, V K Sultanov, S A Inozemtsev
• Journal: Terapevticheskii arkhiv (Ter Arkh) Vol. 61 Issue 8 Pg. 59-62 ( 1989) ISSN: 0040-3660 [Print] Russia (Federation)
• Vernacular Title: Sravnitel'naia otsenka éffektivnosti sukral'fata i H2-gistaminovykh blokatorov pri lechenii iazvennoĭ bolezni.
• PMID: 2573963 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, English Abstract, Journal Article)

Chemical References

• Antacids
• Histamine H2 Antagonists
• Hypnotics and Sedatives
• Parasympatholytics
• Sucralfate
• Cimetidine
• Ranitidine

Topics

• Adolescent
• Adult
• Aged
• Antacids (therapeutic use)
• Cimetidine (therapeutic use)
• Clinical Trials as Topic
• Drug Therapy, Combination
• Histamine H2 Antagonists (therapeutic use)
• Humans
• Hypnotics and Sedatives (therapeutic use)
• Middle Aged
• Parasympatholytics (therapeutic use)
• Peptic Ulcer (drug therapy)
• Ranitidine (therapeutic use)
• Sucralfate (therapeutic use)
• Time Factors