Endovascular embolization of brain arteriovenous malformations with Eudragit-E.

Abstract	Eudragit-E was originally developed as a non-adhesive liquid embolic material in the late 1990s and is a copolymer of methyl and butyl methacrylate and dimethylaminoethyl methacrylate that is dissolved in ethanol and iopamidol. This material has been used for endovascular embolization of brain arteriovenous malformations (AVMs) for some time but is currently not widely used. Because safety and feasibility of Eudragit-E has not been well documented, we here report our experience using this material for treating 22 human brain AVMs. From June 1998 to February 2014, 30 endovascular procedures using Eudragit-E were performed to treat 22 patients, including 14 men and 8 women with a mean age of 41.1 years (15-70 years). The mean follow-up period was 56 months (12-129 months), and the Spetzler-Martin grades were I (4 patients), II (9 patients), III (5 patients), and IV (4 patients). Residual AVMs were treated with stereotactic radiosurgery or surgery. The rate of complete obliteration with embolization alone was 27.3%. The overall obliteration rate after endovascular embolization with/without subsequent stereotactic radiosurgery or surgery was 72.7%. Eudragit-E caused two cases of cerebral infarction. One case of intracerebral hemorrhage due to postoperative hemodynamic changes also occurred. The rate of complications directly related to embolization was 10.0%. The safety and effectiveness of Eudragit-E embolization were satisfactory.
Authors	Goichiro Tamura, Noriyuki Kato, Tomosato Yamazaki, Yoshimitsu Akutsu, Hisayuki Hosoo, Hiromichi Kasuya, Makoto Sonobe
Journal	Neurologia medico-chirurgica (Neurol Med Chir (Tokyo)) Vol. 55 Issue 3 Pg. 253-60 ( 2015) ISSN: 1349-8029 [Electronic] Japan
PMID	25739432 (Publication Type: Case Reports, Journal Article)
Chemical References	Methylmethacrylates Eudragit-E
Topics	Adolescent Adult Aged Embolization, Therapeutic Endovascular Procedures Female Humans Intracranial Arteriovenous Malformations (diagnostic imaging, therapy) Male Methylmethacrylates (therapeutic use) Middle Aged Retrospective Studies Treatment Outcome Young Adult

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