Abstract |
The influence of 2-methyl-6-ethyl-3-hydroxypiridine hemisuccinate on the morphological state of rat brain tissue after the occlusion of left middle cerebral artery has been studied. It was found that 6- and 12-day treatment with 2-methyl-6-ethyl-3-hydroxypyridine hemisuccinate at a dose of 100 mg/kg (intraperitoneal) led to regenerative processes in ischemic brain tissue. The latter treatment duration was most effective.
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Authors | N A Bagdasarian, N G Khostikian, K B Alikhanian, V S Meliksetian, M G Bagdasarian, A G Stepanian, A M Kukhtarova, N R Mirzoian |
Journal | Eksperimental'naia i klinicheskaia farmakologiia
(Eksp Klin Farmakol)
Vol. 77
Issue 12
Pg. 10-3
( 2014)
ISSN: 0869-2092 [Print] Russia (Federation) |
PMID | 25739186
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- 2-methyl-6-ethyl-3-hydroxypyridine hemisuccinate
- Pyridines
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Topics |
- Animals
- Brain
(drug effects, pathology)
- Brain Ischemia
(etiology, pathology, physiopathology, prevention & control)
- Cerebrovascular Circulation
(drug effects)
- Disease Models, Animal
- Infarction, Middle Cerebral Artery
(complications, drug therapy, pathology, physiopathology)
- Male
- Necrosis
- Pyridines
(therapeutic use)
- Rats
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