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[Morphological changes in brain tissues of rat with local permanent ischemia model under the action of 2-methyl-6-ethyl-3-hydroxypyridine hemisuccinate].

Abstract
The influence of 2-methyl-6-ethyl-3-hydroxypiridine hemisuccinate on the morphological state of rat brain tissue after the occlusion of left middle cerebral artery has been studied. It was found that 6- and 12-day treatment with 2-methyl-6-ethyl-3-hydroxypyridine hemisuccinate at a dose of 100 mg/kg (intraperitoneal) led to regenerative processes in ischemic brain tissue. The latter treatment duration was most effective.
AuthorsN A Bagdasarian, N G Khostikian, K B Alikhanian, V S Meliksetian, M G Bagdasarian, A G Stepanian, A M Kukhtarova, N R Mirzoian
JournalEksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) Vol. 77 Issue 12 Pg. 10-3 ( 2014) ISSN: 0869-2092 [Print] Russia (Federation)
PMID25739186 (Publication Type: English Abstract, Journal Article)
Chemical References
  • 2-methyl-6-ethyl-3-hydroxypyridine hemisuccinate
  • Pyridines
Topics
  • Animals
  • Brain (drug effects, pathology)
  • Brain Ischemia (etiology, pathology, physiopathology, prevention & control)
  • Cerebrovascular Circulation (drug effects)
  • Disease Models, Animal
  • Infarction, Middle Cerebral Artery (complications, drug therapy, pathology, physiopathology)
  • Male
  • Necrosis
  • Pyridines (therapeutic use)
  • Rats

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