None.
MEASUREMENTS AND MAIN RESULTS: There were 150 separate runs of
extracorporeal membrane oxygenation for 147 patients with a diagnosis of acute
myocarditis in the
Extracorporeal Life Support Organization database from 1995 through 2011. Survival to hospital discharge was 61%. Nine patients underwent
heart transplantation, and transplant-free survival to discharge was 56%.
Extracorporeal membrane oxygenation was deployed during extracorporeal
cardiopulmonary resuscitation in 31 patients (21% of the cohort). In a multivariate model evaluating pre-
extracorporeal membrane oxygenation and
extracorporeal membrane oxygenation support factors, pre-
extracorporeal membrane oxygenation arrest (adjusted odds ratio, 2.4; 95% CI, 1.1-5.0) and need for higher
extracorporeal membrane oxygenation flows at 4 hours post-
extracorporeal membrane oxygenation cannulation (odds ratio, 2.8; 95% CI, 1.1-7.3) were associated with increased odds of in-hospital mortality. In a second multivariate model evaluating adverse events while on
extracorporeal membrane oxygenation, central nervous system injury (odds ratio, 26.5; 95% CI, 7.3-96.6),
renal failure (odds ratio, 3.6; 95% CI, 1.4-9.3),
arrhythmia (odds ratio, 5.8; 95% CI, 2.2-15.1), and
hyperbilirubinemia (odds ratio, 9.1; 95% CI, 2.6-31.8) were associated with increased odds of in-hospital mortality.
CONCLUSIONS: