Presence of two members of c-erbA receptor gene family (c-erbA beta and c-erbA2) in smallest region of somatic homozygosity on chromosome 3p21-p25 in human breast carcinoma.

Abstract

The loss of heterozygosity of genes on the short arm of chromosome 3 (3p) in human breast carcinomas occurs in a region involved in other malignancies, including renal cell carcinoma, lung cancers, and von Hippel-Lindau disease. This finding suggests the presence of a gene(s) that plays a crucial role in multiple cancers. In our study of 84 informative (heterozygous) primary breast tumors, 30% showed losses of heterozygosity on chromosome 3. The shortest region of homozygosity in primary human breast tumor is located between the DNF15S2 and RAF1 loci in the 3p21-p25 region on the short arm of chromosome 3. This region includes at least two members of the c-erbA steroid/thyroid hormone receptor family (c-erbA beta and c-erbA2) that may be of special relevance to breast cancer. Furthermore, tumors with a loss of heterozygosity of genes on chromosome 3 were previously reported to have frequent allelic deletions on chromosome 11p and amplification of the c-myc proto-oncogene. These results highlight the occurrence of multiple genetic alterations in breast tumors.

• Authors: I U Ali, R Lidereau, R Callahan
• Journal: Journal of the National Cancer Institute (J Natl Cancer Inst) Vol. 81 Issue 23 Pg. 1815-20 (Dec 06 1989) ISSN: 0027-8874 [Print] United States
• PMID: 2573734 (Publication Type: Journal Article)

Chemical References

• DNA, Neoplasm
• MAS1 protein, human
• Proto-Oncogene Mas
• Proto-Oncogene Proteins
• Receptors, Thyroid Hormone

Topics

• Breast Neoplasms (genetics)
• Carcinoma, Intraductal, Noninfiltrating (genetics)
• Chromosome Deletion
• Chromosome Mapping
• Chromosomes, Human, Pair 3
• DNA, Neoplasm (analysis)
• Female
• Genotype
• Humans
• Polymorphism, Restriction Fragment Length
• Proto-Oncogene Mas
• Proto-Oncogene Proteins (analysis)
• Receptors, Thyroid Hormone