Abstract |
The innate immune system detects microbes and abnormal self through pattern recognition receptors ( PRRs), which detect molecules that are either specific for microbes (such as lipopolysaccharide), present in much higher concentrations during infection (such as double-stranded RNA), or present in aberrant locations (such as cytosolic DNA) [1]. The Toll-like receptors (TLRs) are the best-described set of PRRs. TLRs are membrane-bound receptors localized on the plasma membrane and in endosomes, the ligand-binding regions of which face the extracellular environment and the endosomal lumen, respectively [1]. In this issue of EMBO Reports, Hu and colleagues report that WD-repeat and FYVE-domain-containing protein 1 (WDFY1) recruits the signaling adaptor TRIF to TLR3 and TLR4, thereby potentiating signaling from these PRRs (Fig 1); [2].
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Authors | Ramya Nandakumar, Søren R Paludan |
Journal | EMBO reports
(EMBO Rep)
Vol. 16
Issue 4
Pg. 397-8
(Apr 2015)
ISSN: 1469-3178 [Electronic] England |
PMID | 25736437
(Publication Type: Journal Article, Comment)
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Chemical References |
- Adaptor Proteins, Vesicular Transport
- Nuclear Proteins
- Toll-Like Receptor 3
- Toll-Like Receptor 4
- Transcription Factors
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Topics |
- Adaptor Proteins, Vesicular Transport
(genetics)
- Humans
- Nuclear Proteins
(genetics)
- Toll-Like Receptor 3
(genetics)
- Toll-Like Receptor 4
(genetics)
- Transcription Factors
(genetics)
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