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A protease inhibition strategy based on acceleration of autolysis.

Abstract
We report on an iconoclastic strategy for inhibiting proteases via autolysis acceleration. We show that proteases can be concentrated and induced to rapidly self-digest by a biocompatible polymer serving as an efficient catalyst. This new generation of protease inhibitors may find applications in the treatment of various protease-dependent diseases.
AuthorsYan Lv, Jianbin Zhang, Hao Wu, Shan Zhao, Yizhe Song, Shujun Wang, Bing Wang, Guojun Lv, Xiaojun Ma
JournalChemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 51 Issue 27 Pg. 5959-62 (Apr 07 2015) ISSN: 1364-548X [Electronic] England
PMID25736424 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Acrylic Resins
  • Alginates
  • Hexuronic Acids
  • Protease Inhibitors
  • Solutions
  • carbopol 940
  • Glucuronic Acid
  • Heparin
  • Dextran Sulfate
  • Trypsin
  • Carboxymethylcellulose Sodium
Topics
  • Acrylic Resins (chemistry)
  • Alginates (chemistry)
  • Animals
  • Carboxymethylcellulose Sodium (chemistry)
  • Cattle
  • Dextran Sulfate (chemistry)
  • Glucuronic Acid (chemistry)
  • Half-Life
  • Heparin (chemistry)
  • Hexuronic Acids (chemistry)
  • Kinetics
  • Pancreas (chemistry, enzymology)
  • Protease Inhibitors (chemistry)
  • Proteolysis
  • Solutions
  • Trypsin (chemistry, isolation & purification)

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