Abstract |
We report on an iconoclastic strategy for inhibiting proteases via autolysis acceleration. We show that proteases can be concentrated and induced to rapidly self-digest by a biocompatible polymer serving as an efficient catalyst. This new generation of protease inhibitors may find applications in the treatment of various protease-dependent diseases.
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Authors | Yan Lv, Jianbin Zhang, Hao Wu, Shan Zhao, Yizhe Song, Shujun Wang, Bing Wang, Guojun Lv, Xiaojun Ma |
Journal | Chemical communications (Cambridge, England)
(Chem Commun (Camb))
Vol. 51
Issue 27
Pg. 5959-62
(Apr 07 2015)
ISSN: 1364-548X [Electronic] England |
PMID | 25736424
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Acrylic Resins
- Alginates
- Hexuronic Acids
- Protease Inhibitors
- Solutions
- carbopol 940
- Glucuronic Acid
- Heparin
- Dextran Sulfate
- Trypsin
- Carboxymethylcellulose Sodium
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Topics |
- Acrylic Resins
(chemistry)
- Alginates
(chemistry)
- Animals
- Carboxymethylcellulose Sodium
(chemistry)
- Cattle
- Dextran Sulfate
(chemistry)
- Glucuronic Acid
(chemistry)
- Half-Life
- Heparin
(chemistry)
- Hexuronic Acids
(chemistry)
- Kinetics
- Pancreas
(chemistry, enzymology)
- Protease Inhibitors
(chemistry)
- Proteolysis
- Solutions
- Trypsin
(chemistry, isolation & purification)
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